MCL1 encodes the protein MCL1, which is a member of the BCL2 family and can result in antiapoptotic activity (Figure 2).[42] MCL1 amplification has been reported in 12% of HCC.[38] There are no FDA approved therapies to address MCL1 copy number amplification at this time, but investigations focused on small molecule inhibitors of MCL1 are underway. This evidence concerns the gene MCL1 and hepatocellular carcinoma.