Treatment of the KG1a, K562 and CMK leukemia cell lines with the GSK-3 inhibitor SB-415286 resulted in GSK-3beta S9 phosphorylation beta-catenin stabilization, cyclin B downregulation, cell growth inhibition, cell cycle arrest at G2/M and apoptosis [289]. The gene discussed is GSK3B; the disease is leukemia.