EB1 represents core element of a dynamic network at the growing microtubule plus-ends and regulate microtubule dynamics through recruitment of others +TIPs [24-25].We previously showed that MTA anti-cancer and anti-angiogenic efficacy correlated with EB1 comet disruption in human neuroblastoma, glioblastoma and endothelial cells [30-32]. This evidence concerns the gene MAPRE1 and neuroblastoma.