More specifically, we found that carbohydrate intake modified the association between six SNPs and T2D: CDKAL1 rs4712523 and FTO rs8050136 in non-Hispanic whites, IGFBP2 rs4402960 and THADA rs7578597 in non-Hispanic blacks, and NOTCH rs10923931 and TSPAN8-LGRS rs7961581 in Mexican Americans. This evidence concerns the gene IGFBP2 and type 2 diabetes mellitus.