CTLA4 and type 1 diabetes mellitus: In humans, single nucleotide polymorphism (SNP) CT60 (rs3087243) in the 3′ untranslated region of human CTLA4 is associated with multiple autoimmune diseases, including type 1 diabetes (T1D), Graves’ disease (GD), rheumatoid arthritis, and celiac disease (10, 13–16).