EGFR and lung adenocarcinoma: More than 50% of lung adenocarcinomas (LAD) from East Asian non-smokers harbor EGFR mutations, and these tumors have been termed oncogene addicted to reflect their dependence on EGFR-mediated pro-survival signaling and their high susceptibility to apoptosis induced by EGFR-TKIs (e.g. gefitinib and erlotinib) (4, –, 7).