SHH and medulloblastoma: MicroRNAs encoded by the miR-17∼92 cluster, also called oncomiR-1, are overexpressed in various cancers (Concepcion et al., 2012; Mogilyansky and Rigoutsos, 2013) including mouse and human medulloblastomas with constitutively activated SHH signaling (Uziel et al., 2009; Northcott et al., 2009).