In addition to Vegfa overexpression, we found that OvCar-3 OPNc-overexpressing cells up-regulate Epdr1, Pdgfa, Tgfbr1, Tnf and Fgfr2, all of which are able to directly or indirectly modulate different aspects of angiogenesis, such as vascular permeability, lymphatic metastasis and tumor-stroma interactions, endothelial cell survival and stable vasculature [42-52]. The gene discussed is TNF; the disease is neoplasm.