Since we observed here that Vegf is one of the most up-regulated OPNc-induced genes and VEGFA is one of the earliest and a key mediator of angiogenesis [13], we attempted to validate part of the data obtained in this Cancer Gene Array by testing the effect of OPNc-conditioned medium (OPNc-CM) on different aspects of angiogenesis stimulation. The gene discussed is VEGFA; the disease is cancer.