The most significant up-regulated genes identified in this tumor model are related to chromosome-end replication (Tert), invasion and metastasis (Plau, Serpine1, Mmp9 and Mmp1), cell adhesion (Itgb3 and Itgav) and angiogenesis (Angpt1 and Vegfa). The gene discussed is ITGB3; the disease is neoplasm.