Infection of C6/36 cells expressing the αDENV-U143-firefly luciferase (FL) group I intron induced significantly less CPE than either untransformed or αDENV-ΔU143-ΔN Bax transformed cells, demonstrating that expression of an active group I intron is able to suppress DENV infection regardless of the 3’ exon used. The gene discussed is BAX; the disease is infection.