The trend in sensitivity upon Wee1 knockdown towards inactive p53 status can be observed when comparing wild-type p53 tumor cell lines (top 7 cell lines with an average 76% viability) to tumor cell lines with deletion/nonsense mutations and the E6 virus that result in cell lines with recognized inactive p53 status (bottom 6 cell lines with an average of 12.5% viability). This evidence concerns the gene TP53 and neoplasm.