Biomarkers such as annexin V, vascular endothelial growth factor (VEGF), CA-125, and soluble intercellular adhesion molecule-1 (sICAM-1/or glycodelin) [Figure 4] in plasma samples have been shown in the multivariate analysis to diagnose endometriosis that was undetectable by ultrasound with a sensitivity of 81% to 90% and a specificity of 63% to 81% [171]. This evidence concerns the gene MUC16 and endometriosis.