Neither depth of wall invasion nor TNM stages significantly influence HO-1 protein expression.Consistent with these findings, the mean optical density of HO-1 expression in CRC tissues was significantly higher than that in normal tissue (Figure 3a), similar results were found for well differentiated tumors compared to moderate/low differentiated tumors (Figure 3b); whereas no significant difference was found between tumors of stage I, II and stage III, IV, as well as between tumors with and without lymph node metastasis (Figure 3c, d). Here, HMOX1 is linked to colorectal carcinoma.