The induction and importance of HO-1 in tumors were verified in murine tumor models in 1990s[16], and by now ample studies reported the upregulated expression HO-1 in many cancer cells[11,16-22], and suggested the involvement and importance of HO-1 in the formation, progression, metastasis and prognosis of cancers[36-38]. The gene discussed is HMOX1; the disease is cancer.