By an immunochemical assay, we found that the HO-1 was expressed in tumor tissues by 72 of 118 (61%) CRC tissues, whereas much lower expression of HO-1 was observed in adjacent non-tumoral tissues and polyp tissues (11 of 37, 29.7%, P < 0.01, Table 2). Here, HMOX1 is linked to colorectal carcinoma.