In view of the mechanisms involved in the roles of HO-1 in cancers, besides the antioxidative, antiapoptotic effect as described above[17,18,32], many factors involved in the growth and invasion of tumors such as vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) were reported to be associated with HO-1. Here, HMOX1 is linked to cancer.