Supporting this hypothesis it has most recently been demonstrated that anti-Notch treatment prevents bone marrow infiltration of human MM cells in a mouse non-obese diabetic/severe combined immunodeficient xenograft model by modulation of the chemokine receptor CXCR4/stromal cell-derived factor-1 system.21 This is consistent with the observation that MOPC315.BM cells similar to human MM cells express CXCR4, which interacts with stromal cell-derived factor-1 on stromal cells for their recruitment to the bone marrow.36 The gene discussed is CXCR4; the disease is Miyoshi myopathy.