We examined the genetic interaction networks derived from gene families with memberslocalized to the the Prader Willi/Angelman syndrome (15q11-13) critical region, theDiGeorge syndrome (22q11) critical region, and the novel PARP8 (5q11) region using a methodpreviously applied to ADHD30; however, hardly any of the mostsignificant genes harbouring significant CNVRs clustered within gene families.Consequently, we broadened our search for gene family interaction networks (GFINs)and searched the entire genome for GFINs with CNVs enriched in autism. The gene discussed is PARP8; the disease is Down syndrome.