GPT and Cirrhosis: After the researchers adjusted the HBeAg status and serum ALT levels, the HBV-DNA level was the strongest predictor of progression to cirrhosis; specifically the relative risks associated with HBV-DNA levels ≥104–105, 105–106, and ≥106 copies/mL were 2.5, 5.6, and 6.5, respectively [83].