In the microenvironment of liver fibrosis with hepatic vasculature and tissue hypoxia alterations, HSCs produce multiple angiogenic factors, including vascular endothelial growth factor (VEGF), PDGF-BB, and angiopoietin 1 or 2, and express angiopoietin 1 receptors [51,52,53]. Here, VEGFA is linked to Hepatic fibrosis.