CCL2 and Hepatic fibrosis: CCL2 (MCP-1) recruits inflammatory Gr1+/Ly6C+-expressing monocytes from the peripheral blood into the injured liver and promotes hepatic fibrosis [19], and CX3CL1 (fractalkine) protects against hepatic fibrosis by controlling the differentiation of infiltrating monocytes into proinflammatory macrophages and the survival of infiltrating monocytes [20].