For example, the ERK1/2 and p38MAPK pathways were shown to be involved in the induction of HO-1 by arsenite in hepatoma cells [37] and only the p38MAPK was shown to mediate the induction of HO-1 by IL-10 in murine macrophages [38]. The gene discussed is HMOX1; the disease is hepatocellular carcinoma.