VitC was found to induce the HO-1 expression in neurons and glial cells [14] and enhance HO-1 expression induced by the heavy metal As3+[15] Murine Hepa 1c1c7 cell lines, but was also shown to attenuate the induction of HO-1 in a sepsis model [16] or by various agents such as moderately oxidized low density lipoprotein [17] and dopamine [18].The latest report by Moretti [19] demonstrated that VitC exerted antidepressant-like effect which was related to the induction of HO-1. The gene discussed is HMOX1; the disease is Sepsis.