To assess the effect of MDSC adoptive transfer in a more physiological context, we made use of a model of type 1 diabetes [34], [35] in which autoimmunity is induced by the injection of CD8+ OT-1 T cells in conjunction with a polyclonal anti-OVA antibody (Ab) into RIP-mOVA transgenic mice (membrane OVA is expressed as a neo-antigen by the pancreatic beta cells under the rat insulin promoter). Here, CD8A is linked to type 1 diabetes mellitus.