In addition, although capsacin has been shown to suppress human fibrosarcoma-induced angiogenesis in chick chorioallantoic membrane assay [23] by inhibiting VEGF-induced proliferation, and capillary-like tube formation of primary cultured human endothelial cells, the effect of this phytochemical on the VEGF expression in NSCLC cell has not yet been explored in detail. The gene discussed is VEGFA; the disease is fibrosarcoma.