To achieve this we used RT-qPCR to compare changes in the expression of the snoRNAs U44 and U47 following doxorubicin treatment in the colorectal cancer cell lines DLD1 and RKO in their wild-type (WT) form and in a form in which DICER had been stably knocked down (KD). This evidence concerns the gene DICER1 and colorectal cancer.