PIK3R1 and obesity due to melanocortin 4 receptor deficiency: Other related pathways were identified such as concentration of bile acids (ALB, ATF3, SCD; P-value  = 3.87×10−4), obesity (ABAT, AQP7 ARID5B, ATF3, DESP1, HBEGF, IDH1, PLIN1, RETSAT, SCD; P-value  = 5.76×10−4), and insulin resistance (ACOX2, ALB, AQP7, ATP2A2, FGF1, PIK3R1, PON2, PPP1R3C, SCD; P-value  = 5.41×10−3) and sensitivity (FABP3, HIF1AN, PIK3R1, SCD; P-value  = 7.39×10−3).