Specifically, two CEBPB binding regions detected in untreated A549, HepG2 (hepatocellular carcinoma), IMR90 (fetal lung fibroblasts), and K562 (immortalized chronic myelogenous leukemia) cells between the TSS and first exon of CRISPLD2 are salient as they have cluster scores of 1000 out of 1000 (all others near/in CRISPLD2 have scores of <435). This evidence concerns the gene CRISPLD2 and hepatocellular carcinoma.