Our findings that CRISPLD2 knockdown increased IL6 and IL8 levels, while DEX increased CRISPLD2 levels, taken together with the study by Wang, et al demonstrating that CRISPLD2 plays a role in endotoxin regulation, suggest that CRISPLD2, in part, may modulate asthma phenotypes by decreasing the ASM inflammatory response to exogenous LPS-containing bacteria. Here, CRISPLD2 is linked to asthma.