One of these genes, cysteine-rich secretory protein LCCL domain-containing, 2 (CRISPLD2; OMIM 612434), had single nucleotide polymorphisms (SNPs) that were nominally associated with two asthma drug response phenotypes (i.e., inhaled corticosteroid response and short-acting bronchodilator response). Here, CRISPLD2 is linked to asthma.