TNF and Disseminated intravascular coagulation: The results of the present study show that under a high temperature environment, rats present with tissue ischemia and damage (increases in the levels of Cr, BUN, AST, ALT and ALP), organ dysfunction (changes in the MAP and HR), hypercoagulable state or disseminated intravascular coagulation (DIC) (increases in the levels of APTT, PT, FDP and D-D) and an excessively activated systemic inflammatory response (increases in the levels of IL-1β, IL-6 and TNF-α).