Further evidence of the cardioprotective role of ACE2 arises from studies conducted on ACE2-knockout mice, where the loss of ACE2 facilitated adverse, post-MI ventricular remodeling (10); furthermore, previous studies have indicated that ACE2 overexpression in MI rats improved cardiac contractility and remodeling (10,11). The gene discussed is ACE2; the disease is myocardial infarction.