The Nogo-A and NgR1 expression levels in the ischemia group were higher at day 14 and 28 following MCAO compared with those in the hypertension group (P<0.05; Tables II and III), however, these increases in Nogo-A and NgR1 expression were attenuated by the EA treatment (P<0.05, vs. ischemia group). Here, RTN4R is linked to hypertensive disorder.