In the present study, it was shown for the first time, to the best of our knowledge, that EA stimulation at GV20 (Baihui) and GV14 (Dazhui) significantly attenuates cerebral ischemia-induced remote cervical spinal cord neuronal loss and changes in GFAP, APP, Nogo-A and NgR1 expression in hypertensive rats. The gene discussed is APP; the disease is brain ischemia.