A number of previous studies have demonstrated that the levels of BNP and NT-proBNP are powerful prognostic markers across a spectrum of acute coronary syndromes (15), from unstable angina and non-ST elevation myocardial infarction to ST elevation myocardial infarction (16–18), as well as in patients with stable angina pectoris (19,20) and even in the absence of significant necrosis (21). This evidence concerns the gene NPPB and angina pectoris.