In adipose tissues, GPR43 may be involved in regulating obesity and energy accumulation, Similarly, Gpr43 mRNA is expressed in WATs, including subcutaneous, perirenal, and epididymal tissues, as well as in 3T3-L1-derived adipocytes and mature adipocytes (12). This evidence concerns the gene FFAR2 and obesity due to melanocortin 4 receptor deficiency.