A randomized, placebo-controlled clinical trial to assess the effects of treatment with the monoamine oxidase-B inhibitor rasagiline (1 mg/day) for 48 weeks in 174 patients with possible or probable MSA-Parkinsonism type, in 39 sites in 12 countries, found no significant difference in progression in the total UMSARS score between the verum and placebo groups (45). This evidence concerns the gene MAOB and Parkinson disease.