Among the ones not previously reported were GBP6, GPR176, SERPINB1, SERPINB3, STAT4, and CLEC2. Some of the 143 annotated transcripts suppressed in differentiating keratinocytes are known to be affected by retinoids, e.g., KRT1, KRT2, FLG and TGM1. The effect on the expression of ARCI-causing genes is given in Table 2. The gene discussed is GBP6; the disease is autosomal recessive congenital ichthyosis.