We found several of the genes causing ARCI and other forms of ichthyosis to be induced during keratinocyte differentiation, i.e., TGM1, ALOXE3, ALOX12B, NIPAL4, CYP4F22, ABCA12, ABHD5, PNPLA1, ELOVL4, LIPN and CERS3 (see Table 2). Here, NIPAL4 is linked to autosomal recessive congenital ichthyosis.