We found several of the genes causing ARCI and other forms of ichthyosis to be induced during keratinocyte differentiation, i.e., TGM1, ALOXE3, ALOX12B, NIPAL4, CYP4F22, ABCA12, ABHD5, PNPLA1, ELOVL4, LIPN and CERS3 (see Table 2). The gene discussed is ABCA12; the disease is ichthyosis.