The FISH-positive MelTUMP and four of the melanomas (80%) showed aberrations in chromosomes 6 and 11, with aneuploidy of RREB1 and CCND1. The remaining melanoma (with ulceration and eventual regional nodal distant metastases) showed aneuploidy in only CCND1 (chromosome 11). The gene discussed is CCND1; the disease is melanoma.