On replacing this study with similar population-based cohort studies from the same Taiwanese population, where Chang et al. [38] was replaced for sulfonylureas and insulin and where Hsieh et al. [39] was replaced for metformin, there was no significant change in overall association of lung cancer with sulfonylureas (OR 1.05, 95% CI 0.90 to 1.20), insulin (OR 1.36, 95% CI 1.18 to 1.53), or metformin (OR 0.86, 95% CI 0.79 to 0.92). Here, INS is linked to lung cancer.