NFKB1 and pancreatic ductal adenocarcinoma: In addition, IL-1α overexpression is correlated with Kras mutation and NF-κB activation in human pancreatic ductal adenocarcinoma specimens and poor survival in pancreatic ductal adenocarcinoma patients [33], suggesting that NF-κB activation by IL-1α/IL-1R signal is important to tumor progression.