We found that low eGFR, hypertension, smoking status and history of atrial fibrillation were significantly associated with elevated TNFα levels, while elevated TNFR1 levels were associated with aging, low eGFR, hypertension, diabetes and PVD, and elevated TNFR2 levels were associated with aging, low eGFR, diabetes and atrial fibrillation. The gene discussed is TNFRSF1B; the disease is hypertensive disorder.