ANXA5 and acute myeloid leukemia: The combinatory effect of DAC and IDA on AML cell apoptosis was observed, and the results showed that the apoptosis rates (Annexin V + and PI-) in the combined group were significantly increased in the U937, HEL and SKM-1 cell lines compared with the control, DAC and IDA groups (all p < 0.001, Figure 4A).