To this effect, Woodard et al. (2008) showed that fluvastatin induced apoptosis potently and limited the proliferation of renal cell carcinoma (RCC) cells in vitro; these effects were mediated by the suppression of AKT phosphorylation/activation, resulting in inhibition of mTOR and p70 S6 kinase. The gene discussed is AKT1; the disease is hereditary clear cell renal cell carcinoma.