Although a role for Ambra1 in skeletal muscle was never proposed before now, our findings are in agreement with other recent studies indicating that autophagy plays a key role in skeletal muscles, as shown by the myopathic phenotype of Atg5 and Atg7 muscle-specific knockout mice [3], [4] and by the connection between autophagy deregulation and muscular dystrophies [5]–[9]. Here, AMBRA1 is linked to muscular dystrophy.