Increased levels of a number of circulating proteins have previously been reported up to 3–5 years prior to the diagnosis of A-NHL including IL-6, IL-10, sCD23, sCD27, sCD30, sCD44, IgE, CRP, and BCA-1/CXCL13[21]–[24], [26]–[28], [30], [35], [36]. This evidence concerns the gene IGHE and non-Hodgkin lymphoma.