ABCB1 and systemic lupus erythematosus: The intracellular concentrations of ginsenoside Rb2, Rc, Rg2, Rg3, Rd, Rb1 and digoxin in L-MDR1 cells were increased by 3.7-, 3.5-, 2.1-, 2.9-, 4.3, 5.1-, and 3.6- fold with the presence of 10.0 μg/mL SLE (Figure 4(D)).