The same PAMP-induced cytokines may, in addition, initiate the down-stream complex interplay between IFN-γ, IL-12, natural killer cells and ‘angiotoxic’ interferon-γ-inducible protein (IP-10) to eventually depress tumor angiogenesis and thus limit tumor growth and induce tumor regression, respectively. The gene discussed is IFNG; the disease is neoplasm.