A recent systematic review on the association between genetic predisposition and dental implant biological complications implied that there is no strong association between specific genetic polymorphism (IL-1, IL-2, IL-6, TNF-α or TGF-β1) and dental implant failure in terms of biological complications although there was a potential link between the IL-1 genotype and peri-implantitis [45]. Here, TNF is linked to Peri-Implantitis.