Several TMED genes are expressed in colon cancer cells (data not shown), but little is known of the nature of specific cargoes (Strating & Martens, 2009) or the functions of individual p24 proteins, although there is evidence for roles in development (Denzel et al, 2000) and the regulation of the innate immune response (Doyle et al, 2012). Here, TMED2 is linked to colonic neoplasm.