Even though the second shRNA against TEAD1 did not yield more metastases, we sought to further address the role of this pathway by targeting YAP1 itself, given that there are multiple TEAD family members with overlapping functions (Sawada et al, 2008; Zhao et al, 2011) and, importantly, that TEAD-YAP1 function has been previously implicated in colon cancer (Lamar et al, 2012; Chen et al, 2012; Rosenbluh et al, 2012). This evidence concerns the gene YAP1 and malignant colon neoplasm.