HNF4A and cancer: This is intriguing in light of reports indicating a tight interaction between the WNT-TCF and HIPPO-TEAD/YAP pathways: YAP1 is regulated by the WNT-TCF pathway (Konsavage et al, 2012), the HIPPO-YAP1 pathway regulates WNT signaling (Varelas et al, 2010), and YAP1 is essential for β-CATENIN-dependent cancers (Rosenbluh et al, 2012).