HNF4A and adenoma: The idea that WNT-TCF signaling is essential from the formation of benign adenomas to the expansion of lethal metastases (Kinzler & Vogelstein, 1996) has led to great efforts to block WNT-TCF function with small molecules for therapeutic purposes, aiming to eradicate so far incurable metastases (Anastas & Moon, 2013).