One possibility is that in metastases, TEAD/YAP1 signaling interacts with HH-GLI instead of WNT-TCF: HH-GLI signaling drives colon cancer metastases (Varnat et al, 2009), and its interaction with TEAD/YAP1 could parallel the interaction described in medulloblastoma (Fernandez-L et al, 2009). This evidence concerns the gene HNF4A and malignant colon neoplasm.