Our present findings through an unbiased screen support the idea that WNT-TCF signaling represses metastases (Varnat et al, 2010): They are consistent with the downregulation of WNT-TCF target gene expression in metastatic vs. non-metastatic human intestinal adenocarcinomas, and with the enhanced metastatic growth of human colon cancer cells with TCF blockade via dnTCF (Varnat et al, 2010). The gene discussed is HNF4A; the disease is colonic neoplasm.