Commonly repressed genes included the colon and colon cancer stem cell genes ASCL2 and LGR5 (Barker et al, 2007; Van der Flier et al, 2007; Zhu et al, 2012) as well as EPHB2, SOX4 and P21, all as compared with control cells after normalization with housekeeping genes (Fig 8A). The gene discussed is LGR5; the disease is colonic neoplasm.