However, the metastatic suppressor function of shTMED3 in HT29 cells, albeit reduced in comparison with CC14, appears consistent with the recent finding that ligand signaling is still required for full WNT-TCF pathway activity and responses in APC-mutant colon cancer cells (Voloshanenko et al, 2013). The gene discussed is APC; the disease is malignant colon neoplasm.