Notwithstanding cell type-dependent variances, the general rescue of the shSOX12- or shTMED3-driven repression of TCF targets by activated β-CATENIN, together with their mimicry of dnTCF (see above), argues for a general effect of the knockdown of SOX12 or TMED3 on canonical WNT-TCF signaling in human colon cancer cells. Here, TMED3 is linked to malignant colon neoplasm.