HNF4A and colonic neoplasm: Co-expression of constitutively active N'Δβ-CATENIN along with shTMED3 or shSOX12 from integrated replication-incompetent lentivectors greatly enhanced the expression of a cohort of TCF targets, reverting their repression by shTMED3 or shSOX12 alone, both in CC14 and in HT29 colon cancer cells (Supplementary Fig S9).