Commonly repressed genes included the colon and colon cancer stem cell genes ASCL2 and LGR5 (Barker et al, 2007; Van der Flier et al, 2007; Zhu et al, 2012) as well as EPHB2, SOX4 and P21, all as compared with control cells after normalization with housekeeping genes (Fig 8A). Here, ASCL2 is linked to malignant colon neoplasm.