Whereas it remains very likely that TMED3 has additional functions and affects many secreted proteins, given that p24 family proteins load different cargoes into Golgi-derived secretory vesicles and that there are less than a dozen p24 proteins (Strating & Martens, 2009), our data suggest a specific requirement for TMED3 in WNT signaling in human colon cancer. The gene discussed is TMED3; the disease is colonic neoplasm.