Although the homolog of TMED3 in Drosophila (logjam; Strating & Martens, 2009) may not be involved in Wnt signaling (Carney & Taylor, 2003), we tested for this possibility in human colon cancer cells since p24 proteins are multifunctional (Boltz et al, 2007; Strating & Martens, 2009) and TMED5 affects WNT1 secretion in 293T cells (Buechling et al, 2011). Here, TMED5 is linked to malignant colon neoplasm.