Given that several SOX genes, including SOX2, SOX4, SOX11 and SOX12, are expressed in colon cancer cells (data not shown) and that the cofactor activity we define for SOX12 is similar to that of SOX4 (Sinner et al, 2007; Dy et al, 2008; Sarkar & Hochedlinger, 2013), it is surprising that the knockdown of SOX12 is not compensated by other SOXC subfamily members as it is the case in mouse embryonic development (Hoser et al, 2008; Dy et al, 2008; Bhattaram et al, 2010). This evidence concerns the gene SOX4 and malignant colon neoplasm.