TMED3 and malignant colon neoplasm: In this sense, the switch in predominant morphogenetic pathway target expression (WNT to HH) we detect after interference with SOX12 or TMED3 supports and expands previous results with dnTCF4 (Varnat et al, 2010) and the idea that it promotes and/or tracks a change in tumor cell identity from tissue-specific, crypt-like (for colon cancer) to more embryonic-like metastatic states.