Our present findings through an unbiased screen support the idea that WNT-TCF signaling represses metastases (Varnat et al, 2010): They are consistent with the downregulation of WNT-TCF target gene expression in metastatic vs. non-metastatic human intestinal adenocarcinomas, and with the enhanced metastatic growth of human colon cancer cells with TCF blockade via dnTCF (Varnat et al, 2010). Here, HNF4A is linked to malignant colon neoplasm.