BRAF and melanoma: Indeed, Stat3 is activated by phosphorylation in melanoma cells that acquired an invasive phenotype following treatment with U0126 or with the BRAF-inhibitor SB590885, and Stat3 knockdown or its inhibition with CPA-7 prevented the appearance of an invasive phenotype and increased cell death in the presence of U0126 or SB590885 (103).