Moreover, wortmannin or MK-2206 have been shown to enhance the apoptotic cascade activation and the consequent death after TRAIL treatment of melanoma cell lines, selected for different susceptibility profiles to soluble TRAIL, through a mechanism involving increased reactive oxygen species (ROS) production and augmented Bax activation via phosphorilation of threonine-167 (124). Here, TNFSF10 is linked to melanoma.