TNFSF10 and melanoma: In a recent study, Zimmerman et al showed that activation of Wnt/β-catenin signaling increased TRAIL-induced apoptosis in melanoma cells: A375 cells treated with CHIR99021 (GSK-3 inhibitor) exhibited a dose-dependent increase in the percentage of cells undergoing apoptosis upon rhTRAIL treatment compared to control treated cells (with AXIN-1 playing a major role in apoptosis-sensitization) (131).