The HDAC inhibitor suberoyl bis-hydroxamic acid (SBHA) synergized with soluble TRAIL in vitro to induce mitochondrial-mediated melanoma cell death (127,128), and similar results in terms of cell growth arrest and caspase-dependent apoptosis were obtained with full-length TRAIL, delivered from an adenoviral vector, in combination with the HDAC inhibitor vorinostat (suberoylanilide hydroxamic acid (SAHA)) (129). This evidence concerns the gene HDAC9 and melanoma.