There are eight mammalian IAPs: neuronal apoptosis inhibitory protein (NAIP), cellular inhibitor of apoptosis (cIAP)-1, cIAP-2, X-linked inhibitor of apoptosis (XIAP), Survivin, Apollon, IAP-like protein-2 (ILP-2) and ML-IAP/Livin; many of them have been implicated in melanoma resistance to different therapies (17). This evidence concerns the gene BIRC3 and melanoma.