MAP2K7 and melanoma: Indeed, dual blockade of MEK/BRAFV600E (with PD184352, PLX4720 or vemurafenib) and MET (with crizotinib, SU11274 or MET-specific siRNA) resulted in reversal of drug resistance and reduced the proliferation of melanoma cell lines, which was restored by exogenous HGF (29,109).