It is located 60 kb upstream of a tyrosine-protein kinase transmembrane receptor gene, ROR1. The SNP lies within a potential cancer-specific enhancer observed as open chromatin for multiple cancer cell lines such as A549, LNCaP and MCF-7, but not in normal NHLF and HMEC cell lines (Figure 6; Additional file 12). Here, ROR1 is linked to cancer.