APOE and diabetes mellitus: Forbes et al. (2004) showed no effect of aminoguanidine, an inhibitor of AGE formation and the thiazolium derivative, ALT‐711, a putative AGE crosslink breaker, on lesion size in the aortic arch of STZ‐treated Apoe−/− mice maintained on a chow diet when analyzed 20 weeks after induction of diabetes, whereas in a separate study, both agents lessened renal pathology in diabetic Apoe−/− mice (Lassila et al. 2004).