Exposure of cultured endothelial cells to hyperglycemia upregulates expression of RAGE, S100B, and HMGB1 and this can be prevented by overexpression of GLO1 (Yao and Brownlee 2009), whereas genetic inactivation of RAGE prevents the diabetes‐induced downregulation of GLO1 expression in kidneys of OVE26 mice, a mouse model of type 1 diabetes (Reiniger et al. 2010). This evidence concerns the gene GLO1 and diabetes mellitus.