APOE and Hypercholesterolemia: The hypercholesterolemia that occurs in the Apoe−/− mice following STZ administration has been considered a shortcoming in this mouse model of human diabetic cardiovascular disease (Renard and Van Obberghen 2006; Hsueh et al. 2007; Kanter et al. 2007; Ramasamy and Goldberg 2010) and, in our case, may mask any macrovascular protective effects that are due to reducing dicarbonyl stress through overexpression of GLO1.