In rat models of CKD, including aging (Jung et al. 2004; Akintola et al. 2008), the ZDF‐SHHR model of rapidly progressing chronic renal dysfunction (Jung et al. 2004), and the Ren2 transgenic rat model of fibrosis and proteinuria (Whaley‐Connell et al. 2011, 2012), loss of N‐cadherin and α‐catenin expression has been demonstrated. The gene discussed is CDH2; the disease is chronic kidney disease.