The median PSA level at time of detection of metastatic disease was 5.0 ng/ml (range 0.2 – 45.4 ng/ml) compared to 5.1 ng/ml (0.6-116.7 ng/ml) for patients screened with FDG-PET-CT and choline PET-CT, respectively (p = 0.71). This evidence concerns the gene KLK3 and metastatic neoplasm.