NFE2L2 and colorectal adenoma: It was found that minor NRF2 −617A allele was significantly associated with oxidant-induced acute lung injury among patients of African and European descent with major trauma (Marzec et al. 2007), but it was not associated with gastric carcinogenesis in Japanese patients (Arisawa et al. 2008) or colorectal adenomas in European patients (Tijhuis et al. 2008).