Higher prevalence of SOD2 16Val alleles in control group was observed in the US case–control study (Terry et al. 2005), Caucasians from EPIC cohort (Vineis et al. 2007) and two studies on Turkish individuals (Cengiz et al. 2007; Kucukgergin et al. 2012), which may suggest protective role of SOD2 16Val allele in BC risk. Here, SOD2 is linked to breast cancer.