Demonstration that HIF1α is capable of interacting with c-Myc, Notch and more recently FOXA2 to direct ordered transcription and enhance tumor formation [9]–[11] leaves open the possibility that the HIF1 complex is a core transcriptional unit that modulates multiple intracellular signaling networks, many of which may be involved in metastatic transformation. The gene discussed is HIF1A; the disease is neoplasm.