We found that IGF+HGF administration combined with cell transplantation significantly increased the rate of Sca-1+/CD31− cell engraftment, reduced infarct size, and further attenuated post-acute MI LV structural and functional remodeling as compared to the results achieved by injection of Sca-1+/CD31− cells alone. This evidence concerns the gene IGF1 and myocardial infarction.