The resulting hypoxic condition (PO2<10 mmHg [∼1.5% O2]) prevents degradation of hypoxia-inducible factor-1α (HIF-1α) through VHL tumor suppressor, allowing trans-activation of pro-angiogenic factors, among which the most notable is vascular endothelial growth factor (VEGF) [8]–[11]. Here, HIF1A is linked to neoplasm.