In a model of hypoxia-induced pulmonary hypertension, these mice were reported to exhibit impaired endothelial cell mobilization and recruitment to pulmonary endothelium and lack hypoxia activation of eNOS in lungs observed in wild type mice; pulmonary hypertension was ameliorated by wild type bone marrow transplantation [85]. The gene discussed is NOS3; the disease is pulmonary hypertension.