Lastly, endogenous and exogenous EPO has been found to exert anti-inflammatory effects on white adipose tissue macrophages during diet induced obesity that was exacerbated in mice with EpoR restricted to erythroid tissue, thus implicating the EPO/EpoR axis in regulation of macrophage infiltration and subset composition in white fat [72]. This evidence concerns the gene EPOR and obesity due to melanocortin 4 receptor deficiency.